微阵列与显微镜：平衡通量与分辨率
Microarrays and the microscope: balancing throughput with resolution.
作者信息
Coppola Giovanni, Geschwind Daniel H
机构信息
Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
出版信息
J Physiol. 2006 Sep 1;575(Pt 2):353-9. doi: 10.1113/jphysiol.2006.112623. Epub 2006 Jun 29.
Abstract
The cellular complexity of the brain is a major issue in the planning, execution and interpretation of microarray studies. Recent technical advances allow for high-throughput study of specific cell populations and circuits. Here we review representative examples of currently available methods that allow high resolution and specificity in brain microarray studies, while maintaining the goal of comprehensive, high-throughput analysis.
摘要
大脑的细胞复杂性是微阵列研究的规划、实施和解读中的一个主要问题。最近的技术进展使得对特定细胞群体和神经回路进行高通量研究成为可能。在这里，我们回顾了当前可用方法的代表性实例，这些方法在大脑微阵列研究中能够实现高分辨率和特异性，同时保持全面、高通量分析的目标。
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