Turksoy R N, Safaii H S
Fertil Steril. 1975 Jul;26(7):634-7.
Serum luteinizing hormone, estradiol, 17-hydroxyprogesterone, and progesterone determinations were performed in five normally ovulating women prior to, during, and after prostaglandin F2alpha (PGF2alpha was infusion. A total of 75 mg of PGF2alpha was infused over 48 hours, beginning on the 4th day of the luteal phase. Endometrial biopsies were obtained at the completion of the infusion. In all patients, transient decreases in serum progesterone and 17-hydroxyprogesterone levels were observed during PGF2alpha infusion. Subsequent rises in the serum progesterone and 17-hydroxyprogesterone levels were observed 24 hours after completion of the infusion. There was no significant change in serum luteinizing hormone levels. Premature menstrual bleeding occurred with 24 to 72 hours after the termination of the infusion, while progesterone and 17-hydroxyprogesterone levels were still elevated. Endometrial histology revealed focal stromal necrosis in the presence of the normal secretory endometrium. It is concluded that, in the human, PGF2alpha at this dose and time schedule is not luteolytic.
在五名正常排卵的女性中，于前列腺素F2α（PGF2α）输注前、输注期间和输注后进行了血清促黄体生成素、雌二醇、17-羟孕酮和孕酮的测定。从黄体期第4天开始，在48小时内共输注75毫克PGF2α。输注结束时获取子宫内膜活检样本。在所有患者中，PGF2α输注期间观察到血清孕酮和17-羟孕酮水平短暂下降。输注结束24小时后观察到血清孕酮和17-羟孕酮水平随后升高。血清促黄体生成素水平无显著变化。输注终止后24至72小时出现月经提前出血，而此时孕酮和17-羟孕酮水平仍升高。子宫内膜组织学显示在正常分泌期子宫内膜存在局灶性间质坏死。得出的结论是，在人类中，此剂量和时间安排的PGF2α不具有溶黄体作用。
