Pu Y S, Tsai T C, Chiu T Y, Hsieh T S, Chen J, Chen S C, Lin M C, Hsu T C
Department of Urology, National Taiwan University Hospital, Taipei, R.O.C.
J Formos Med Assoc. 1991 May;90(5):498-503.
Immunosuppressive acidic protein (IAP) is a non-specific immunoreactive protein arising from inflammatory or malignant conditions in the human body. We determined the IAP levels in 65 cases with urological malignancies and in 31 cases with benign diseases as a control group during a 9-month period. There were significantly higher serum levels of IAP in cases of bladder transitional cell carcinoma (p = 0.025), prostate adenocarcinoma (p less than 0.00001) and upper urinary tract urothelial cancer (kidney and/or ureter, p = 0.013) as compared with those of the control group. Significant differences in IAP between different tumor stages were found in the bladder cancer group with high stage cases having higher IAP levels (p less than 0.0005). However, no significant differences were found between different tumor gradings. Most of the prostate cancer patients had extremely high IAP values (1,029 +/- 490 micrograms/ml) in this study. Renal cell carcinoma and testicular tumors showed no statistical differences from the control group (p = 0.89 and 0.37, respectively). No differences could be found in the different age groups (by decades) or sexes. The serum IAP level can be a good non-specific tumor marker for bladder cancer staging and probably a good follow-up tool for most urological malignancy patients.
免疫抑制酸性蛋白（IAP）是一种因人体炎症或恶性疾病产生的非特异性免疫反应蛋白。在9个月的时间里，我们测定了65例泌尿系统恶性肿瘤患者以及作为对照组的31例良性疾病患者的IAP水平。与对照组相比，膀胱移行细胞癌（p = 0.025）、前列腺腺癌（p < 0.00001）和上尿路尿路上皮癌（肾和/或输尿管，p = 0.013）患者的血清IAP水平显著更高。在膀胱癌组中，不同肿瘤分期的IAP存在显著差异，高分期病例的IAP水平更高（p < 0.0005）。然而，不同肿瘤分级之间未发现显著差异。在本研究中，大多数前列腺癌患者的IAP值极高（1,029 ± 490微克/毫升）。肾细胞癌和睾丸肿瘤与对照组无统计学差异（分别为p = 0.89和0.37）。在不同年龄组（按十年划分）或性别之间未发现差异。血清IAP水平可作为膀胱癌分期的良好非特异性肿瘤标志物，可能也是大多数泌尿系统恶性肿瘤患者的良好随访工具。
