Vistisen Bodil, Mu Huiling, Høy Carl-Erik
BioCentrum-DTU, Section of Biochemistry & Nutrition, Technical University of Denmark, Lyngby, Denmark.
Eur J Nutr. 2006 Sep;45(6):363-8. doi: 10.1007/s00394-006-0607-x. Epub 2006 Jun 29.
Consumption of specific structured triacylglycerols, MLM (M = medium chain fatty acid, L = long chain fatty acid), delivers fast energy and long chain fatty acids to the organism.
The purpose of the present study was to compare lymphatic absorption of (13)C-labeled MLM and (13)C-labeled LLL in rats. Stable isotope labeling enables the separation of the endogenous and exogenous fatty acids.
Lymph was collected during 24 h following administration of MLM or LLL. Lymph fatty acid composition and (13)C-enrichment were determined and quantified by gas chromatography combustion isotope ratio mass spectrometry.
The recovery of 18:1n-9 was higher after administration of LLL compared with MLM (58.1% +/- 7.4% and 29.1% +/- 3.9%, respectively, P < 0.001). This may be due to a higher chylomicron formation stimulated by a higher amount of long chain fatty acids in the intestine after LLL compared with MLM administration. This was confirmed by the tendencies of higher lymphatic transport of endogenous fatty acids.
The study revealed a higher lymphatic recovery of the administered long chain fatty acids after LLL compared with MLM consumption.
食用特定的结构化三酰甘油，即中链脂肪酸-长链脂肪酸甘油三酯（MLM，M代表中链脂肪酸，L代表长链脂肪酸），能为机体提供快速能量和长链脂肪酸。
本研究旨在比较大鼠对13C标记的MLM和13C标记的LLL（L代表长链脂肪酸，此处为三个长链脂肪酸甘油三酯）的淋巴吸收情况。稳定同位素标记能够区分内源性和外源性脂肪酸。
在给予MLM或LLL后24小时内收集淋巴液。通过气相色谱燃烧同位素比率质谱法测定并量化淋巴液中的脂肪酸组成和13C富集情况。
给予LLL后，18:1n-9的回收率高于给予MLM后（分别为58.1%±7.4%和29.1%±3.9%，P<0.001）。这可能是因为与给予MLM相比，给予LLL后肠道中长链脂肪酸含量更高，刺激了更多乳糜微粒的形成。内源性脂肪酸淋巴转运增加的趋势证实了这一点。
研究表明，与食用MLM相比，食用LLL后，所给予的长链脂肪酸的淋巴回收率更高。
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