Hung C R, Lee C H
Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan, Republic of China.
J Pharm Pharmacol. 1991 Aug;43(8):559-63. doi: 10.1111/j.2042-7158.1991.tb03536.x.
The effect of cimetidine on the acidified tannic acid-induced back diffusion of gastric acid and mucosal damage was investigated in the vagotomized rat. After intragastric irrigation for 1 to 3 h, tannic acid (20-500 mg kg-1) produced a dose-related increase in gastric volume and the loss of luminal H+. The change of mucosal permeability to the electrolyte, either the loss of H+ or the gain of Na+, K+, and Ca2+, induced by tannic acid was significantly diminished by the combination with intragastric cimetidine. However, intravenous injection of cimetidine did not protect this damage and back diffusion of acid neutralized intragastric cimetidine did not reduce the back diffusion of acid and Na+, K+, and Ca2+ output provoked by acid solution. Thus, the neutralizing action of cimetidine seems responsible.
在迷走神经切断的大鼠中研究了西咪替丁对酸化单宁酸诱导的胃酸反向弥散和粘膜损伤的影响。在胃内灌注1至3小时后，单宁酸（20 - 500毫克/千克）使胃容积呈剂量相关增加，管腔内氢离子丢失。单宁酸诱导的粘膜对电解质通透性的改变，即氢离子丢失或钠、钾、钙的增加，与胃内给予西咪替丁联合使用时显著减轻。然而，静脉注射西咪替丁并不能保护这种损伤，且中和胃酸的胃内西咪替丁并不能减少酸溶液引起的酸反向弥散以及钠、钾、钙的排出。因此，西咪替丁的中和作用似乎起了作用。
