维生素K预防措施能否预防子宫内暴露于酶诱导抗癫痫药物的新生儿出血？
Does vitamin K prophylaxis prevent bleeding in neonates exposed to enzyme-inducing antiepileptic drugs in utero?
作者信息
Rezvani Massoud, Koren Gideon
机构信息
Motherisk Program.
出版信息
Can Fam Physician. 2006 Jun;52(6):721-2.
Abstract
QUESTION
One of my epileptic patients takes carbamazepine. She is 36 weeks pregnant and has asked me whether she should start vitamin K to prevent neonatal bleeding. Does current evidence support this practice?
ANSWER
Recent evidence does not support the notion that newborns of women treated with enzyme-inducing anticonvulsant drugs are at increased risk of hemorrhagic disease. Antenatal vitamin K can be prescribed on an individualized basis in certain circumstances, such as imminent premature delivery.
摘要
问题
我的一位癫痫患者正在服用卡马西平。她已怀孕36周，问我是否应该开始补充维生素K以预防新生儿出血。目前的证据支持这种做法吗？
答案
最近的证据并不支持接受酶诱导抗惊厥药物治疗的女性所生新生儿患出血性疾病风险增加这一观点。在某些情况下，如即将早产时，可根据个体情况开具产前维生素K处方。
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