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孕期抗癫痫药物与新生儿出血性疾病：最新进展。

Antiepileptic drugs in pregnancy and hemorrhagic disease of the newborn: an update.

机构信息

Motherisk Team, Hospital for Sick Children, Toronto.

出版信息

Can Fam Physician. 2010 Dec;56(12):1291-2.

PMID:21156891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3001920/
Abstract

QUESTION

What is the current evidence regarding the association between hemorrhagic disease of the newborn and maternal use of hepatic enzyme-inducing antiepileptic drugs (eg, carbamazepine, phenobarbitone, topiramate)?

ANSWER

Women with epilepsy who take enzyme-inducing antiepileptic drugs should be advised that there is no adequate evidence to support or refute taking vitamin K in late pregnancy to prevent bleeding complications in a newborn.

摘要

问题

关于新生儿出血性疾病与母体使用肝酶诱导抗癫痫药物（如卡马西平、苯巴比妥、托吡酯）之间的关联，目前有哪些证据？

答案

服用酶诱导型抗癫痫药物的癫痫妇女应被告知，没有充分的证据支持或反驳在妊娠晚期服用维生素 K 以预防新生儿出血并发症。

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Antiepileptic drugs in pregnancy and hemorrhagic disease of the newborn: an update.孕期抗癫痫药物与新生儿出血性疾病：最新进展。
Can Fam Physician. 2010 Dec;56(12):1291-2.
2
Does vitamin K prophylaxis prevent bleeding in neonates exposed to enzyme-inducing antiepileptic drugs in utero?维生素K预防措施能否预防子宫内暴露于酶诱导抗癫痫药物的新生儿出血？
Can Fam Physician. 2006 Jun;52(6):721-2.
3
Transplacental vitamin K prevents haemorrhagic disease of infant of epileptic mother.经胎盘给予维生素K可预防癫痫母亲所生婴儿的出血性疾病。
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4
Neonatal haemorrhage following maternal anticonvulsant therapy.母亲接受抗惊厥治疗后新生儿出血
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Prenatal vitamin K1 administration in epileptic women to prevent neonatal hemorrhage: is it effective?癫痫女性产前给予维生素K1预防新生儿出血：是否有效？
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本文引用的文献

1
Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society.实践参数更新：癫痫女性的管理问题——聚焦妊娠（循证综述）：维生素K、叶酸、血药浓度及母乳喂养：美国神经病学学会和美国癫痫协会质量标准小组委员会及治疗与技术评估小组委员会报告
Neurology. 2009 Jul 14;73(2):142-9. doi: 10.1212/WNL.0b013e3181a6b325. Epub 2009 Apr 27.
2
Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants?服用抗惊厥药的孕妇需要进行产前维生素K预防吗？
Am J Obstet Gynecol. 2004 Apr;190(4):882-3. doi: 10.1016/j.ajog.2004.01.041.
3
Enzyme-inducing antiepileptic drugs in pregnancy and the risk of bleeding in the neonate.孕期酶诱导抗癫痫药物与新生儿出血风险
Neurology. 2002 Feb 26;58(4):549-53. doi: 10.1212/wnl.58.4.549.
4
Vitamin K in neonates: how to administer, when and to whom.新生儿维生素K：如何给药、何时给药以及给谁给药。
Paediatr Drugs. 2001;3(1):1-8. doi: 10.2165/00128072-200103010-00001.
5
Practice parameter: management issues for women with epilepsy (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology.实践参数：癫痫女性的管理问题（总结声明）。美国神经病学学会质量标准小组委员会报告。
Epilepsia. 1998 Nov;39(11):1226-31. doi: 10.1111/j.1528-1157.1998.tb01316.x.
6
Vitamin K.维生素K。
Lancet. 1995 Jan 28;345(8944):229-34. doi: 10.1016/s0140-6736(95)90227-9.
7
Transplacental vitamin K prevents haemorrhagic disease of infant of epileptic mother.经胎盘给予维生素K可预防癫痫母亲所生婴儿的出血性疾病。
Lancet. 1982 May 29;1(8283):1247. doi: 10.1016/s0140-6736(82)92371-6.
8
Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy.孕期使用抗惊厥药物治疗导致的新生儿凝血缺陷。
Lancet. 1970 Feb 7;1(7641):265-8. doi: 10.1016/s0140-6736(70)90636-7.
9
Parenteral vitamin K1: the effective prophylaxis against haemorrhagic disease for all newborn infants.肠外维生素K1：对所有新生儿出血性疾病的有效预防措施。
N Z Med J. 1990 Mar 14;103(885):95-6.
10
Haemorrhagic disease of the newborn in the British Isles: two year prospective study.不列颠群岛新生儿出血性疾病：两年前瞻性研究
BMJ. 1991 Nov 2;303(6810):1105-9. doi: 10.1136/bmj.303.6810.1105.