Morken Nils-Halvdan, Källen Karin, Jacobsson Bo
Department of Obstetrics and Gynecology, Telemark Hospital, Skien, Norway.
Am J Obstet Gynecol. 2006 Jul;195(1):154-61. doi: 10.1016/j.ajog.2006.01.019.
This study was undertaken to assess whether deviations from normal fetal growth are associated with spontaneous preterm delivery.
A population-based study was performed, using Swedish Medical Birth Register data from 1991 through 2001. The total population comprised 1,007,648 singleton births. Intrauterine-derived growth standards were used to identify individual standard deviation (SD) from expected birth weight. Spontaneous preterm infants were compared with infants born after spontaneous labor at term. Results were obtained by using multiple logistic regression analysis.
Associations between smaller than population mean and spontaneous preterm birth were evident for all gestational age groups. The largest risk was found at 28 to 31 gestational weeks and birth weight less than -3 SD (OR: 13.3; 95% CI: 10.3-17.2). Spontaneous preterm infants born at 34 to 36 gestational weeks weighed 1 to 1.9 SD (OR: 1.1; 95% CI: 1.1-1.2) or 2 to 2.9 SD (OR: 1.6; 95% CI: 1.5-1.7) above the expected mean more often.
Deviation of fetal growth from the expected mean is associated with spontaneous preterm delivery.
本研究旨在评估胎儿生长偏离正常水平是否与自发性早产相关。
采用基于人群的研究方法，使用1991年至2001年瑞典医学出生登记数据。总人口包括1,007,648例单胎分娩。采用宫内生长标准来确定个体出生体重与预期出生体重的标准差（SD）。将自发性早产婴儿与足月自然分娩的婴儿进行比较。通过多元逻辑回归分析得出结果。
在所有孕周组中，出生体重低于人群均值与自发性早产之间的关联均很明显。在孕28至31周且出生体重低于-3 SD时风险最大（比值比：13.3；95%置信区间：10.3 - 17.2）。孕34至36周出生的自发性早产婴儿体重高于预期均值1至1.9 SD（比值比：1.1；95%置信区间：1.1 - 1.2）或2至2.9 SD（比值比：1.6；95%置信区间：1.5 - 1.7）的情况更为常见。
胎儿生长偏离预期均值与自发性早产相关。
