序贯经皮与持续口服激素替代疗法对绝经后女性血浆总同型半胱氨酸水平影响的比较：一项随机、安慰剂对照研究。
A comparison of the effects of sequential transdermal versus continuous orally administered hormone replacement therapies on plasma total homocysteine levels in postmenopausal women: a randomized, placebo-controlled study.
作者信息
Kurtay G, Ozmen B
机构信息
Menopause Clinic, Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University, Ankara, Turkey.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2007 Feb;130(2):206-11. doi: 10.1016/j.ejogrb.2006.05.021. Epub 2006 Jun 30.
OBJECTIVE
The objective was to determine the effects of transdermal and oral hormone replacement therapies on plasma total homocysteine levels in postmenopausal women.
MATERIAL AND METHODS
One hundred and ten postmenopausal patients were enrolled in the study. Participants were randomized into three groups: in Group A (n = 31) oral continuous combined therapy and in Group B (n = 30) transdermal sequential hormone replacement therapy were given for 6 months. A placebo was administered orally to the control group (Group C, n = 30). Serum homocysteine levels were studied prior to and after 6 months of treatment in all groups.
RESULTS
There were no statistical significant differences in mean serum homocysteine levels among the groups prior to the study. The mean homocysteine levels after 6 months in Groups A-C were also similar.
CONCLUSIONS
Serum homocysteine levels alter with neither oral continuous nor sequential transdermal hormone replacement therapy.
目的
确定经皮和口服激素替代疗法对绝经后女性血浆总同型半胱氨酸水平的影响。
材料与方法
110名绝经后患者参与了本研究。参与者被随机分为三组：A组（n = 31）给予口服连续联合疗法，B组（n = 30）给予经皮序贯激素替代疗法，治疗6个月。对照组（C组，n = 30）口服安慰剂。在所有组治疗6个月之前和之后研究血清同型半胱氨酸水平。
结果
研究前各组间平均血清同型半胱氨酸水平无统计学显著差异。A - C组6个月后的平均同型半胱氨酸水平也相似。
结论
口服连续或经皮序贯激素替代疗法均不会改变血清同型半胱氨酸水平。
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