Seidl S, Hausmann R, Neisser J, Janisch H-D, Betz P
Institute for Forensic Medicine, University Erlangen-Nürnberg, Universitätsstrasse 22, 91054 Erlangen, Germany.
Int J Legal Med. 2007 Jul;121(4):281-5. doi: 10.1007/s00414-006-0109-7. Epub 2006 Jul 5.
The severity and duration of cognitive performance capacity deficits after intravenous administration of propofol were determined using the validated psychological test procedure syndrome short test (SKT), a simple reaction test and original driving licence exam questions. The test battery was performed before, immediately after, as well as 1 and 2 h after propofol administration in 23 persons. Immediately after propofol anaesthesia, six individuals had a slight performance loss, and four subjects showed mild deficits, consistent with medium organic neuropsychologic disorder or dementia. The status of the subjects rapidly changed for the better, and 2 h after propofol anaesthesia, only one person (4%) showed slight deficits of memory and attention. Therefore, it is suggested that patients refrain from any participation in road traffic for at least 2 h after propofol anaesthesia. Driving a car should not be admitted until an interval of 6 h has elapsed.
通过使用经过验证的心理测试程序综合征简短测试（SKT）、简单反应测试和原始驾驶执照考试问题，来确定静脉注射丙泊酚后认知表现能力缺陷的严重程度和持续时间。在23名受试者中，于丙泊酚给药前、给药后立即以及给药后1小时和2小时进行了测试组测试。丙泊酚麻醉后立即有6人表现略有下降，4人显示轻度缺陷，这与中度器质性神经心理障碍或痴呆相符。受试者的状况迅速好转，丙泊酚麻醉后2小时，只有1人（4%）表现出轻微的记忆和注意力缺陷。因此，建议患者在丙泊酚麻醉后至少2小时内不要参与任何道路交通活动。直到间隔6小时后才应允许驾驶汽车。
