Sporny Stanisław, Musiał Jacek
Medical University of Lodz, Poland.
Endokrynol Pol. 2005 Nov-Dec;56(6):946-51.
A pheochromocytoma is a neoplasm composed of cells which synthesize and release catecholamines. These tumors produce the hypertension which can be cured with surgical excision of the lesion. The pathological picture of pheochromocytomas is varied and nothing but the presence of metastases can determine aggressiveness of this neoplasm. Current studies try to look for other biological markers which can separate malignant tumors before they metastasize. It allows to target with more effective therapy. Many studies analyze details of microscopic features of these tumors, immunohistochemical markers and molecular disorders. It seems that the most important factor in estimation of aggressiveness of pheochromocytomas is PASS scale. The detection of high expression of telomerase and hTERT and high proliferative activity, measured by immunohistochemistry with the MIB-1 antibody supports most strongly biological malignancy of pheochromocytoma.
嗜铬细胞瘤是一种由合成并释放儿茶酚胺的细胞组成的肿瘤。这些肿瘤会引发高血压，通过手术切除病灶可治愈。嗜铬细胞瘤的病理表现多样，只有出现转移才能确定该肿瘤的侵袭性。目前的研究试图寻找其他生物标志物，以便在恶性肿瘤发生转移之前将其区分出来，从而进行更有效的靶向治疗。许多研究分析了这些肿瘤的微观特征细节、免疫组化标志物和分子紊乱情况。在评估嗜铬细胞瘤的侵袭性方面，最重要的因素似乎是PASS量表。通过使用MIB-1抗体进行免疫组化检测到端粒酶和hTERT的高表达以及高增殖活性，最有力地支持了嗜铬细胞瘤的生物学恶性特征。
