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[热带地区癫痫筛查:毛里塔尼亚一份调查问卷的验证]

[Dépistage de l'épilepsie en zones tropicales: validation d'un questionnaire en Mauritanie].

作者信息

Diagana M, Preux P M, Tuillas M, Ould Hamady A, Druet-Cabanac M

机构信息

Centre neuro-psychiatrique, Nouakchott, Mauritanie.

出版信息

Bull Soc Pathol Exot. 2006 May;99(2):103-7.

Abstract

Prevalence of epilepsy in developing countries is considered to be 2 to 5 times superior to the industrialized countries. In tropical areas, the diagnosis of epilepsy is still reliant on the clinic and requires a precise semiological description. A good epidemiological and clinical research requires standardized and validated screening tools. The objective of this work was to evaluate the validity of the screening module of the investigation questionnaire on epilepsy in tropical areas, in Nouakchott, Mauritania. All the patients included in the study were examined at first by a neurologist, then directed towards an investigator who asked the 5 screening items of the investigation questionnaire. Any person answering "yes" at least one question was regarded as "suspected of epilepsy" by the investigator. Secondly the neurologist re-examined the subjects and confirmed the diagnosis. The sensitivity and the specificity of the module of screening were calculated. On the whole, 236 patients were included in the study 131 had answered "yes" at least one of the questions of the module of screening and was regarded as "suspected" of epilepsy (55.5%) by the questionnaire. The diagnosis of epilepsy was made for 82 subjects by the neurologist. The sensitivity of the module of screening of the epilepsy was 95.1% (CI 95%: 87.3-98.4) and specificity was 65.6% (CI 95%: 57.5-72.9). The screening module of the investigation questionnaire of epilepsy in tropical zones, made up only by 5 questions, has diagnosis qualities acceptable and comparable with those reported in the literature. The use of this tool integrated in a more general questionnaire of investigation of the. epilepsy proves to be an essential instrument in conducting epidemiologic studies in epileptology' in tropical zones.

摘要

发展中国家癫痫的患病率被认为是工业化国家的2至5倍。在热带地区,癫痫的诊断仍依赖于临床,且需要精确的症状学描述。良好的流行病学和临床研究需要标准化且经过验证的筛查工具。这项工作的目的是在毛里塔尼亚努瓦克肖特评估热带地区癫痫调查问卷筛查模块的有效性。所有纳入研究的患者首先由神经科医生进行检查,然后由一名调查员询问调查问卷的5个筛查项目。任何至少对一个问题回答“是”的人被调查员视为“疑似癫痫”。其次,神经科医生对这些受试者进行复查并确认诊断。计算筛查模块的敏感性和特异性。总体而言,236名患者纳入研究,131人至少对筛查模块的一个问题回答“是”,根据问卷被视为“疑似”癫痫(55.5%)。神经科医生对82名受试者做出了癫痫诊断。癫痫筛查模块的敏感性为95.1%(95%置信区间:87.3 - 98.4),特异性为65.6%(95%置信区间:57.5 - 72.9)。热带地区癫痫调查问卷的筛查模块仅由5个问题组成,具有可接受的诊断质量,与文献报道的相当。将该工具整合到更全面的癫痫调查问卷中,被证明是在热带地区开展癫痫流行病学研究的重要工具。

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