Clark Mel, Payne Joshua
Integris Baptist Medical Center, Oklahoma, USA.
J Okla State Med Assoc. 2006 Jun;99(6):363-7.
Elevated cardiac troponin I or T levels are caused by cardiac injury. Such elevations in patients with acute coronary syndrome are crucial in terms of diagnosis, risk stratification and guiding therapy. Cardiac troponins are also often elevated in patients with chronic renal failure and in a wide range of other medical conditions in which the pathophysiology of acute coronary syndrome (plaque rupture and thrombosis) is not present. This review discusses the differences between cardiac troponin and other cardiac markers and the importance of bedside testing. The literature on elevated cardiac troponins in patients with acute coronary syndrome, patients without acute coronary syndrome and patients with chronic renal failure is summarized. The significance of elevated cardiac troponins in each group as it relates to prognosis and guiding treatment options is discussed.
心肌肌钙蛋白I或T水平升高是由心脏损伤引起的。在急性冠状动脉综合征患者中，这种升高对于诊断、风险分层和指导治疗至关重要。慢性肾衰竭患者以及许多其他不存在急性冠状动脉综合征病理生理机制（斑块破裂和血栓形成）的疾病患者中，心肌肌钙蛋白水平也常常升高。本综述讨论了心肌肌钙蛋白与其他心脏标志物之间的差异以及床旁检测的重要性。总结了关于急性冠状动脉综合征患者、无急性冠状动脉综合征患者和慢性肾衰竭患者中心肌肌钙蛋白升高的文献。讨论了每组中心肌肌钙蛋白升高与预后及指导治疗选择的相关性。
