Yamasaki Akira, Tomita Katsuyuki, Chikumi Hiroki, Tatsukawa Toshiyuki, Shigeoka Yasushi, Nakamoto Masaki, Hashimoto Kiyoshi, Hasegawa Yasuyuki, Shimizu Eiji
Division of Internal Medicine and Molecular Therapeutics, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Tottori Prefecture, 683-8503, Japan.
Anticancer Res. 2006 May-Jun;26(3B):2213-6.
Middle lobe syndrome, caused mainly by benign inflammatory diseases, such as chronic bronchitis and bronchiectasis, is manifested clinically as a chronic cough with sputum production. The prognosis associated with this syndrome is considered good in most cases which are caused by chronic inflammatory diseases. A patient who developed lung cancer in the course of long-term treatment for right middle lobe syndrome is described. A 63-year-old woman was admitted to our hospital with complaints of right iliac bone pain. She had been treated for chronic bronchitis and bronchiectasis associated with middle lobe syndrome for 16 years before admission. Work-up of a lung adenocarcinoma originating from the right middle lobe disclosed bone metastasis to the illium. Tumorigenesis in association with middle lobe syndrome has not yet been reported, but this first reported case suggests the need to be alert to the possibility.
中叶综合征主要由慢性支气管炎和支气管扩张等良性炎症性疾病引起，临床症状为慢性咳嗽伴咳痰。在大多数由慢性炎症性疾病引起的病例中，该综合征的预后被认为良好。本文描述了一名在长期治疗右中叶综合征过程中发生肺癌的患者。一名63岁女性因右髂骨疼痛入院。入院前，她因与中叶综合征相关的慢性支气管炎和支气管扩张接受了16年的治疗。对起源于右中叶的肺腺癌检查发现已发生髂骨转移。尚未有与中叶综合征相关的肿瘤发生的报道，但这例首次报道的病例提示有必要警惕这种可能性。
