FHIT在食管上皮及癌组织中的表达：与饮酒、吸烟及多中心癌变的关系
Expression of FHIT in esophageal epithelium and carcinoma: reference to drinking, smoking and multicentric carcinogenesis.
作者信息
Morita Masaru, Oyama Tsunehiro, Nakata Shoji, Ono Kenji, Sugaya Masakazu, Uramoto Hidetaka, Yoshimatsu Takashi, Hanagiri Takeshi, Sugio Kenji, Yasumoto Kosei
机构信息
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812- 8582, Japan.
出版信息
Anticancer Res. 2006 May-Jun;26(3B):2243-8.
BACKGROUND
Both alcohol consumption and cigarette smoking are risk factors for esophageal cancer. The purpose of this study was to clarify whether the fragile histidine triad (FHIT) is their target gene in esophageal carcinogenesis as well as in multicentric carcinogenesis.
PATIENTS AND METHODS
The expression of FHIT was immunohistochemically examined in the squamous cell carcinoma as well as in the normal esophageal epithelium of 55 cases with esophageal cancer.
RESULTS
The median drinking indices (DIs) were 546 and 1092 (p<0.01) in cases with positive FHIT expression and those with a diminished expression in the esophageal epithelium, respectively. Furthermore, the incidences of intra-esophageal multiple cancer were 44% and 13%, respectively (p<0.05). Regarding the expression in cancer lesions, the median DIs were 280 and 721 in positive and diminished cases, respectively (p=0.081).
CONCLUSION
A loss of FHIT expression is associated not only with alcohol-induced esophageal carcinogenesis, but also with multicentric carcinogenesis.
背景
饮酒和吸烟均为食管癌的危险因素。本研究旨在阐明脆性组氨酸三联体（FHIT）基因在食管癌发生以及多中心癌发生过程中是否为其靶基因。
患者与方法
采用免疫组织化学方法检测55例食管癌患者鳞状细胞癌组织及正常食管上皮组织中FHIT的表达。
结果
食管上皮组织中FHIT表达阳性和表达减弱的患者，其饮酒指数（DI）中位数分别为546和1092（p<0.01）。此外，食管内多发癌的发生率分别为44%和13%（p<0.05）。在癌组织中的表达方面，FHIT表达阳性和减弱的患者，其DI中位数分别为280和721（p=0.081）。
结论
FHIT表达缺失不仅与酒精诱导的食管癌发生有关，还与多中心癌发生有关。
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