在 exploratory surgery（此处可能为“探查性手术 ”）期间检测出的晚期食管癌患者姑息治疗方案的结果。
Outcome of palliative care regimens in patients with advanced oesophageal cancer detected during explorative surgery.
作者信息
Pultrum Bareld B, van Westreenen Henderik L, Mulder Nanno H, van Dullemen Hendrik M, Plukker John Th M
机构信息
Department of Surgical Oncology, University Medical Center Groningen (UMCG), University of Groningen, The Netherlands.
出版信息
Anticancer Res. 2006 May-Jun;26(3B):2289-93.
BACKGROUND
The outcome of different palliative regimens was investigated in patients with incurable oesophageal carcinoma identified during surgical exploration.
PATIENTS AND METHODS
Between January 1992 and December 2002, 203 patients with oesophageal cancer underwent surgery after a standard staging procedure including computer tomography and endoscopic ultrasonography. The data from 78 patients, rendered incurable at exploration and who subsequently underwent palliative interventions, were analysed retrospectively.
RESULTS
The median survival in the whole group was 8.9 (1-105) months. Patients treated with chemotherapy had a higher median survival of 11.6 months compared with that of the other palliatively-treated patients: 8.4 months (p=0.003). Overall, intraluminal stenting was the palliative measure of dysphagia in 25 patients (32.3%).
CONCLUSION
Patients with incurable oesophageal carcinoma have a poor overall survival of less than 9 months. Stenting is frequently (32%) needed for ultimate palliation of dysphagia after primary treatment. In a selective group, palliative chemotherapy offered a survival benefit compared with other treatment modalities.
背景
对手术探查时确诊的无法治愈的食管癌患者采用不同姑息治疗方案的疗效进行了研究。
患者与方法
1992年1月至2002年12月期间，203例食管癌患者在接受包括计算机断层扫描和内镜超声检查在内的标准分期检查后接受了手术。对78例在探查时被判定无法治愈且随后接受姑息治疗的患者的数据进行了回顾性分析。
结果
整个组的中位生存期为8.9（1 - 105）个月。接受化疗的患者中位生存期较高，为11.6个月，而其他接受姑息治疗的患者为8.4个月（p = 0.003）。总体而言，25例患者（32.3%）采用腔内支架置入术作为吞咽困难的姑息治疗措施。
结论
无法治愈的食管癌患者总体生存期较差，不到9个月。在初始治疗后，为最终缓解吞咽困难，频繁（32%）需要进行支架置入。在一个选择性组中，与其他治疗方式相比，姑息化疗可带来生存获益。
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