Brøndum-Nielsen Karen, Gerdes Anne-Marie A
Kennedy Instituttet--Statens Øjenklinik, Gl. Landevej 7, DK-2600 Glostrup.
Ugeskr Laeger. 2006 Jun 12;168(24):2350-4.
The article describes the state of the art in the management of hereditary cancer predisposition syndromes in Denmark. Genetic counselling in relation to monogenic cancer syndromes is now well established in the Danish health care system, after a remarkable development during the past 10 years. The cornerstones of this activity are identification of persons at risk through elucidation of the family history of cancer, risk assessment, genetic testing and genetic counselling of the counselee and her/his family. During the counselling process, ethical, legal and psychosocial issues are addressed. Persons identified as being at risk are offered assistance in the form of standardized screening programmes or/and prophylactic surgery, when relevant and when opted for by the patient. The ultimate purpose is to reduce cancer mortality, and the hope is that future developments will lead to the identification of effective methods of true cancer prophylaxis.
本文描述了丹麦遗传性癌症易感性综合征管理的最新状况。在过去10年取得显著发展之后，丹麦医疗保健系统中针对单基因癌症综合征的遗传咨询现已得到充分确立。这项工作的基石包括通过阐明癌症家族史来识别有风险的人群、风险评估、基因检测以及为咨询对象及其家人提供遗传咨询。在咨询过程中，会探讨伦理、法律和社会心理问题。被确定为有风险的人在相关情况下且患者选择时，会以标准化筛查计划或/和预防性手术的形式获得帮助。最终目的是降低癌症死亡率，并且希望未来的发展将带来真正有效的癌症预防方法的发现。
