Bleser Scott D
Bellbrook Medical Center, Inc, 4336 State Route 725, Bellbrook, OH 45305-2742, USA.
J Fam Pract. 2006 Jul;55(7):587-93.
Increased fiber intake through diet or fiber supplements is an appropriate initial therapy for chronic constipation. Osmotic and stimulant laxatives may be administered to patients who do not respond to more conservative measures if the limitations of these agents are explained. Tegaserod, a selective 5-hydroxytryptamine type 4 (5-HT4) receptor partial agonist, is more effective than placebo at relieving symptoms of chronic idiopathic constipation in patients younger than 65 years of age. Patients with suspected defecation disorders and those with treatment-refractory symptoms should be referred to a gastroenterologist for further evaluation.
通过饮食或纤维补充剂增加纤维摄入量是慢性便秘的合适初始治疗方法。如果向患者解释了这些药物的局限性，对于对更保守措施无反应的患者可给予渗透性和刺激性泻药。替加色罗是一种选择性5-羟色胺4型（5-HT4）受体部分激动剂，在缓解65岁以下慢性特发性便秘患者的症状方面比安慰剂更有效。疑似排便障碍的患者和有难治性症状的患者应转诊给胃肠病学家进行进一步评估。
