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Inability to express fimbriae results in impaired ability of Haemophilus influenzae b to colonize the nasopharynx.

作者信息

Weber A, Harris K, Lohrke S, Forney L, Smith A L

机构信息

Division of Infectious Disease, Children's Hospital and Medical Center, Seattle, Washington 98105.

出版信息

Infect Immun. 1991 Dec;59(12):4724-8. doi: 10.1128/iai.59.12.4724-4728.1991.

Abstract

We cloned into the structural fimbrial subunit gene from a fimbriated Haemophilus influenzae b a 1.5-kb kanamycin resistance gene. The resultant strain (RKAW5) was tested by Southern analysis, hemagglutination, and electron-micrographic examination to confirm gene inactivation. In comparison with the parent, RKAW5 exhibited a significant decrease in adherence to human buccal epithelial cells and in nasal colonization of yearling rhesus monkeys.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1a/259107/0d3c86ea613a/iai00048-0444-a.jpg

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