生物活性玻璃S53P4用于额窦闭塞术：长期临床经验

Bioactive glass S53P4 in frontal sinus obliteration: a long-term clinical experience.

作者信息

Peltola Matti, Aitasalo Kalle, Suonpää Jouko, Varpula Matti, Yli-Urpo Antti

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Turku University Hospital, FIN-20521 Turku, Finland.

出版信息

Head Neck. 2006 Sep;28(9):834-41. doi: 10.1002/hed.20436.

DOI:10.1002/hed.20436

PMID:16823870

Abstract

BACKGROUND

Synthetic, osteoconductive, and antimicrobial bioactive glass (BAG) has been used in many surgical applications.

METHODS

BAG was used as obliteration material in a series of osteoplastic frontal sinus operations on 42 patients suffering from chronic frontal sinusitis, which could not be cured with other means of treatment.

RESULTS

Accurate obliteration of sinuses was achieved in 39 patients. Uneventful recovery and clinical outcome were seen in 92% of the patients. Histopathologic samples harvested at 1, 5, and 10 years after obliteration revealed a healing process progressing from the fibrous tissue phase to bone formation with scattered fibrous tissue and bony obliteration maintaining BAG granule remnants. Fourier-transform infrared (FTIR) studies showed bone produced by BAG to be similar to natural frontal bone. Micorobiologic cultures obtained with histologic samples revealed no growth of bacteria.

CONCLUSIONS

BAG appears to be a reliable frontal sinus obliteration material, providing favorable conditions for total bony sinus obliteration.

摘要

背景

合成的、具有骨传导性和抗菌性的生物活性玻璃（BAG）已用于许多外科手术应用中。

方法

在一系列针对42例慢性额窦炎患者的骨成形性额窦手术中，BAG被用作填塞材料，这些患者无法通过其他治疗方法治愈。

结果

39例患者实现了鼻窦的精确填塞。92%的患者恢复顺利，临床效果良好。填塞后1年、5年和10年采集的组织病理学样本显示，愈合过程从纤维组织阶段发展到骨形成，伴有散在的纤维组织和维持BAG颗粒残余的骨填塞。傅里叶变换红外光谱（FTIR）研究表明，BAG产生的骨与天然额骨相似。从组织学样本中获得的微生物培养显示没有细菌生长。