Jafari Nazanin, Habashi Mina Seyed, Hashemi Alireza, Shirazi Reza, Tanideh Nader, Tamadon Amin
Persian Gulf Marine Biotechnology Research Center, Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
Department of Endodontics, School of Dentistry, Bushehr University of Medical Sciences, Bushehr, Iran.
Biomater Res. 2022 Jul 6;26(1):31. doi: 10.1186/s40824-022-00274-6.
Bioactive glasses are a group of bioceramic materials that have extensive clinical applications. Their properties such as high biocompatibility, antimicrobial features, and bioactivity in the internal environment of the body have made them useful biomaterials in various fields of medicine and dentistry. There is a great variation in the main composition of these glasses and some of them whose medical usage has been approved by the US Food and Drug Administration (FDA) are called Bioglass. Bioactive glasses have appropriate biocompatibility with the body and they are similar to bone hydroxyapatite in terms of calcium and phosphate contents. Bioactive glasses are applied in different branches of dentistry like periodontics, orthodontics, endodontics, oral and maxillofacial surgery, esthetic and restorative dentistry. Also, some dental and oral care products have bioactive glasses in their compositions. Bioactive glasses have been used as dental implants in the human body in order to repair and replace damaged bones. Other applications of bioactive glasses in dentistry include their usage in periodontal disease, root canal treatments, maxillofacial surgeries, dental restorations, air abrasions, dental adhesives, enamel remineralization, and dentin hypersensitivity. Since the use of bioactive glasses in dentistry is widespread, there is a need to find methods and extensive resources to supply the required bioactive glasses. Various techniques have been identified for the production of bioactive glasses, and marine sponges have recently been considered as a rich source of it. Marine sponges are widely available and many species have been identified around the world, including the Persian Gulf. Marine sponges, as the simplest group of animals, produce different bioactive compounds that are used in a wide range of medical sciences. Numerous studies have shown the anti-tumor, anti-viral, anti-inflammatory, and antibiotic effects of these compounds. Furthermore, some species of marine sponges due to the mineral contents of their structural skeletons, which are made of biosilica, have been used for extracting bioactive glasses.
生物活性玻璃是一类具有广泛临床应用的生物陶瓷材料。它们具有诸如高生物相容性、抗菌特性以及在人体内部环境中的生物活性等性质，使其成为医学和牙科各个领域有用的生物材料。这些玻璃的主要成分有很大差异，其中一些已被美国食品药品监督管理局（FDA）批准用于医学用途的被称为生物活性玻璃。生物活性玻璃与人体具有适当的生物相容性，并且在钙和磷含量方面与骨羟基磷灰石相似。生物活性玻璃应用于牙科的不同分支，如牙周病学、正畸学、牙髓病学、口腔颌面外科、美容和修复牙科。此外，一些口腔护理产品的成分中含有生物活性玻璃。生物活性玻璃已被用作人体牙科植入物，以修复和替换受损骨骼。生物活性玻璃在牙科的其他应用包括用于牙周疾病、根管治疗、颌面外科手术、牙齿修复、气磨、牙科粘合剂、牙釉质再矿化和牙本质过敏。由于生物活性玻璃在牙科中的使用广泛，需要找到方法和广泛资源来供应所需的生物活性玻璃。已经确定了各种生产生物活性玻璃的技术，并且海洋海绵最近被认为是其丰富来源。海洋海绵广泛存在，世界各地已鉴定出许多物种，包括波斯湾的物种。海洋海绵作为最简单的动物群体，产生不同的生物活性化合物，这些化合物被广泛应用于医学科学领域。大量研究表明了这些化合物的抗肿瘤、抗病毒、抗炎和抗生素作用。此外，一些海洋海绵物种由于其由生物二氧化硅构成的结构骨架中的矿物质含量，已被用于提取生物活性玻璃。
