Mesa Circe, de León Joel, Rigley Kevin, Fernández Luis E
Vaccine's Department, Centre of Molecular Immunology, 216 esq 15, Atabey, Playa, CP 16040, C. Habana, Cuba.
Vaccine. 2006 Apr 12;24 Suppl 2:S2-42-3. doi: 10.1016/j.vaccine.2005.01.114.
Recent findings in the interactions between pathogens and the innate immune system, particularly with dendritic cells (DC), have opened new opportunities for adjuvants designs. We have elaborated a new approach, in which gangliosides are incorporated into the outer membrane complex of Neisseria meningitidis to form very small size proteoliposomes (VSSP). VSSP demonstrated a unique ability to render highly tolerated gangliosides immunogenic. These results drove our attention to the immunopotentiating properties of VSSP. Here we examined the VSSP adjuvant effect on dendritic cell activation. Also the role of LPS on this effect was dissected. This study reveals that VSSP is a potent adjuvant for DC activation.
病原体与固有免疫系统，特别是与树突状细胞（DC）之间相互作用的最新研究成果，为佐剂设计带来了新机遇。我们精心设计了一种新方法，即将神经节苷脂掺入脑膜炎奈瑟菌的外膜复合物中，以形成极小尺寸的蛋白脂质体（VSSP）。VSSP展现出一种独特能力，可使原本耐受性很强的神经节苷脂具有免疫原性。这些结果让我们将注意力投向了VSSP的免疫增强特性。在此，我们研究了VSSP对树突状细胞激活的佐剂效应。同时，我们还剖析了脂多糖（LPS）在此效应中的作用。这项研究表明，VSSP是一种用于激活树突状细胞的强效佐剂。
