Benn Christine Stabell, Diness Birgitte Rode, Fisker Ane Baerent, Christoffersen Dorthe, Friis Henrik
Guinea-Bissau/Statens Serum Institut, Bandim Health Project, og Københavns Universitet.
Ugeskr Laeger. 2006 Jun 19;168(25):2442-5.
Many large intervention trials have shown that high-dose vitamin A supplementation decreases overall childhood mortality rates by 23-30%, making it one of the most cost-effective interventions in low-income countries. However, with regard to morbidity and the immunological mechanisms behind the beneficial effect on mortality rates, the results are less clear. Furthermore, vitamin A seems to be beneficial in some but not all age groups, and smaller doses may be even better than higher doses. It seems likely that by pursuing these inconsistent observations, vitamin A supplementation programmes can be optimised.
许多大型干预试验表明，补充高剂量维生素A可使儿童总体死亡率降低23% - 30%，这使其成为低收入国家最具成本效益的干预措施之一。然而，关于发病率以及死亡率有益影响背后的免疫机制，结果尚不清楚。此外，维生素A似乎对某些年龄组有益，但并非对所有年龄组都有益，而且较小剂量可能比较大剂量效果更好。通过探究这些不一致的观察结果，似乎有可能优化维生素A补充计划。
