取代苯并吡喃异吲哚的合成及其抗增殖活性：一类新型细胞毒性化合物
Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: a new class of cytotoxic compounds.
作者信息
Hadjipavlou Christiana, Kostakis Ioannis K, Pouli Nicole, Marakos Panagiotis, Pratsinis Harris, Kletsas Dimitris
机构信息
Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
出版信息
Bioorg Med Chem Lett. 2006 Sep 15;16(18):4822-5. doi: 10.1016/j.bmcl.2006.06.074. Epub 2006 Jul 7.
PMID:16824751
Abstract
A series of novel aminosubstituted benzopyranoisoindoles possessing structural analogy to an active nitracrine metabolite are reported. The compounds exhibited interesting cytotoxic activity against a panel of cell lines, which was maximized by the presence of both 1-dialkylaminoethyl and 3-nitro substituents.
摘要
报道了一系列与活性硝吖啶代谢物具有结构相似性的新型氨基取代苯并吡喃异吲哚。这些化合物对一组细胞系表现出有趣的细胞毒性活性，当同时存在1-二烷基氨基乙基和3-硝基取代基时，这种活性达到最大。
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