Mitwally Mohamed F, Albuarki Hafsa, Diamond Michael P, Abuzeid Mostafa, Fakih Michael M
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, USA.
J Minim Invasive Gynecol. 2006 Jul-Aug;13(4):296-301. doi: 10.1016/j.jmig.2006.03.005.
To explore the effectiveness (success, safety, and complications) of a novel technique of gestational sac aspiration in the management of early pregnancy failure as an alternative to dilation and evacuation (D&E) and conservative management.
Prospective historical cohort study comparing effectiveness of gestational sac aspiration (study group) to conservative management (control group) with follow-up until negative quantitative beta human chorionic gonadotropin testing is achieved (Canadian Task Force classification II-1).
An infertility treatment center.
Among 60 women with failed early pregnancies that were achieved by in vitro fertilization or intrauterine insemination, 20 underwent gestational sac aspiration, whereas 40 chose conservative management.
Gestational sac aspiration was done by transvaginal ultrasound-guided needle aspiration under conscious sedation. Aspirated tissue was sent for karyotyping. Both study and control (conservative management) groups received close follow-up with ultrasound and serial beta human chorionic gonadotropin measurements.
There was no significant difference in age, infertility factor, or treatment between study and control groups. Mean gestational age was 8 versus 6 weeks in study and control groups, respectively (p < .05). One and 11 patients required D&E in the study and control groups, respectively (p < .05). Karyotyping was successful in all except one patient in the study group. Chromosomal abnormalities were found in 36% of products of conception. No significant complications occurred
Gestational sac aspiration is a simple and safe outpatient technique that is more effective than conservative management of early pregnancy failure and less invasive than D&E. Moreover, the technique provides a high probability of obtaining a noncontaminated adequate gestation tissue sample for chromosomal study.
探讨一种新型妊娠囊抽吸技术在早期妊娠失败管理中的有效性（成功率、安全性和并发症），作为扩张刮宫术（D&E）和保守治疗的替代方法。
前瞻性历史队列研究，比较妊娠囊抽吸术（研究组）与保守治疗（对照组）的有效性，随访至定量β-人绒毛膜促性腺激素检测呈阴性（加拿大工作组分类II-1）。
一家不孕症治疗中心。
在60例通过体外受精或宫内人工授精实现的早期妊娠失败的女性中，20例行妊娠囊抽吸术，40例选择保守治疗。
在清醒镇静下经阴道超声引导针吸术进行妊娠囊抽吸。吸出的组织送去做染色体核型分析。研究组和对照组（保守治疗组）均接受超声和连续β-人绒毛膜促性腺激素测量的密切随访。
研究组和对照组在年龄、不孕因素或治疗方面无显著差异。研究组和对照组的平均孕周分别为8周和6周（p<0.05）。研究组和对照组分别有1例和11例患者需要进行扩张刮宫术（p<0.
