Korabiowska Monika, Voltmann Jann, Hönig Johannes F, Bortkiewicz Pawel, König Frank, Cordon-Cardo Carlos, Jenckel Frederike, Ambrosch Petra, Fischer Gösta
Institute of Pathology, Reinhard-Nieter Hospital, Academic Hospital of the University Göttingen, Wilhelmshaven, Germany.
Anticancer Res. 2006 May-Jun;26(3A):2101-5.
The relevance of double-strand DNA repair genes has been demonstrated in several tumours. The main aim of this study was to analyse the expression of the heterodimers Ku70 and Ku80, building regulatory subunits of the DNA-dependent protein kinase in 40 oral carcinomas. Ku70 expression was found in 87.5% of grade 1 and grade 3 tumours and in 82.9% of grade 2 carcinomas. Ku80 presence was noted in 87.5% of grade 1 tumours, 82.9% of grade 2 tumours and in all grade 3 tumours. Ku70-positive cells were present in 90.5% of tumours without and in 80% of tumours with lymphatic metastases. A similar relationship was found for Ku80 expression. Additionally, the expression of Ku70 was highly significantly related to smoking habits. Our results demonstrated that defects of DNA double-strand repair genes play an important role in the tumour progression of oral carcinomas.
双链DNA修复基因的相关性已在多种肿瘤中得到证实。本研究的主要目的是分析40例口腔癌中DNA依赖性蛋白激酶的调节亚基异二聚体Ku70和Ku80的表达。在1级和3级肿瘤的87.5%以及2级癌的82.9%中发现了Ku70表达。在87.5%的1级肿瘤、82.9%的2级肿瘤和所有3级肿瘤中均检测到Ku80的存在。在无淋巴转移的肿瘤中，90.5%存在Ku70阳性细胞，在有淋巴转移的肿瘤中，80%存在Ku70阳性细胞。Ku80表达也发现了类似的关系。此外，Ku70的表达与吸烟习惯高度显著相关。我们的结果表明，DNA双链修复基因缺陷在口腔癌的肿瘤进展中起重要作用。
