在发展中国家钩虫流行地区，驱虫是否应纳入产前套餐？
Should deworming be included in antenatal packages in hookworm-endemic areas of developing countries?
作者信息
Larocque Renée, Gyorkos Theresa W
机构信息
Department of Epidemiology and Biostatistics, McGill University, Montreal, QC.
出版信息
Can J Public Health. 2006 May-Jun;97(3):222-4. doi: 10.1007/BF03405590.
BACKGROUND
WHO recommends antenatal (after the first trimester) deworming for pregnant women who live in areas where the prevalence of hookworm infection exceeds 20-30%. However, deworming has not been included in antenatal care packages in most developing countries.
METHODS
A review of articles publishing original data identified primarily through Medline was conducted using subject heading terms and text words for "deworming", "pregnant women", "hookworm", "anthelminthic", "anthelmintic", "albendazole", "mebendazole", "pregnancy" and their combinations. Bibliographies of retrieved articles were scanned to identify any additional relevant documents.
RESULTS
Five articles examined the benefits of antenatal deworming. All provided evidence favourable to deworming, in terms of both maternal and infant outcomes. Comparison of outcome measures could be improved with a more standardized approach to outcome ascertainment and reporting.
CONCLUSION
The evidence base for the inclusion of deworming in antenatal care packages in hookworm-endemic areas is mostly observational in nature. Future research should be directed towards 1) strengthening the evidence base with empirical data from randomized controlled trials, and 2) furthering our understanding related to government uptake of the WHO policy on deworming.
背景
世界卫生组织建议，对于居住在钩虫感染率超过20%-30%地区的孕妇，应在孕期（孕中期之后）进行驱虫。然而，在大多数发展中国家，驱虫尚未被纳入产前保健套餐。
方法
通过使用“驱虫”“孕妇”“钩虫”“驱虫药”“抗蠕虫药”“阿苯达唑”“甲苯达唑”“妊娠”及其组合的主题词和文本词，对主要通过医学期刊数据库检索到的发表原始数据的文章进行综述。对检索到的文章的参考文献进行筛选，以确定任何其他相关文件。
结果
五篇文章研究了产前驱虫的益处。所有文章均提供了有利于驱虫的证据，涉及母婴结局。采用更标准化的结局确定和报告方法可改善结局指标的比较。
结论
在钩虫流行地区将驱虫纳入产前保健套餐的证据基础大多是观察性的。未来的研究应致力于：1）通过随机对照试验的经验数据加强证据基础；2）加深我们对政府采纳世界卫生组织驱虫政策的理解。
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