Riera Marta, Redko Yulia, Leung Jeffrey
Institut des Sciences du Végétal, Centre National de la Recherche Scientifique UPR2355, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
FEBS Lett. 2006 Jul 24;580(17):4160-5. doi: 10.1016/j.febslet.2006.06.064. Epub 2006 Jun 30.
The Arabidopsis thaliana RNA binding protein UBA2a is the closest homologue of the Vicia faba AKIP1 (56% identity). Like AKIP1, UBA2a is a constitutively-expressed nuclear protein and in response to ABA it is also reorganized within the nucleus in "speckles" suggesting a possible role of this protein in the regulation of mRNA metabolism during ABA signaling. AKIP1 interacts with, and is phosphorylated by, the upstream ABA-activated protein kinase AAPK. We have investigated if a pathway similar to that described in Vicia faba also exists in Arabidopsis. Our results showed that despite the resemblance between the corresponding Vicia and Arabidopsis proteins, it appears that the function of UBA2a is independent of OST1 phosphorylation.
拟南芥RNA结合蛋白UBA2a是蚕豆AKIP1最接近的同源物（同一性为56%）。与AKIP1一样，UBA2a是一种组成型表达的核蛋白，响应脱落酸时，它也会在细胞核内重新组织成“斑点”，这表明该蛋白在脱落酸信号传导过程中对mRNA代谢的调节可能发挥作用。AKIP1与上游脱落酸激活的蛋白激酶AAPK相互作用并被其磷酸化。我们研究了拟南芥中是否也存在类似于蚕豆中描述的途径。我们的结果表明，尽管相应的蚕豆和拟南芥蛋白之间存在相似性，但UBA2a的功能似乎独立于OST1磷酸化。
