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1-O-单酰基或12-O-单酰基、1,12-O-二酰基以及11,12-脱水穿心莲内酯A 7,14-丙酮化物的合成及其细胞毒性活性。

Synthesis of 1-O-monoacyl or 12-O-monoacyl, 1-,12-O-diacyl-, and 11,12-dehydrated excisanin A 7,14-acetonides and their cytotoxic activity.

作者信息

Aoyagi Yutaka, Nishioka Yumi, Tobe Fukuya, Hasuda Tomoyo, Takeya Koichi, Gui Ming-Yu, Jin Yong-Ri, Li Xu-Wen

机构信息

School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

出版信息

Bioorg Med Chem. 2006 Sep 1;14(17):5802-11. doi: 10.1016/j.bmc.2006.05.058. Epub 2006 Jul 7.

DOI:10.1016/j.bmc.2006.05.058
PMID:16828562
Abstract

1-O-Monoacyl, 12-O-monoacyl, 1-,12-O-diacyl, and 11,12-dehydrated excisanin A 7,14-acetonides were synthesized from excisanin A isolated from Rabdosia excisa. The structure and cytotoxic activity relationships (SAR) of the natural parent ent-kaurene diterpenes and these semisynthetic analogues were studied by using P388 murine leukemia cells.

摘要

从溪黄草中分离得到溪黄草素A，以此合成了1 - O - 单酰基、12 - O - 单酰基、1,12 - O - 二酰基和11,12 - 脱水溪黄草素A 7,14 - 丙酮化物。利用P388小鼠白血病细胞研究了天然母体对映 - 贝壳杉烯二萜及其这些半合成类似物的结构与细胞毒性活性关系（构效关系）。

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