来自阿富汗紫菀的松香烷二萜类化合物及其半合成类似物的细胞毒性。
Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues.
作者信息
Aoyagi Yutaka, Takahashi Yoshinao, Satake Yudai, Takeya Koichi, Aiyama Ritsuo, Matsuzaki Takeshi, Hashimoto Shusuke, Kurihara Teruo
机构信息
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
出版信息
Bioorg Med Chem. 2006 Aug 1;14(15):5285-91. doi: 10.1016/j.bmc.2006.03.047. Epub 2006 Apr 19.
Seven known abietane diterpenoids and 11-O- and 12-O-acetylcarnosic acids were isolated from a methanol extract of Perovskia abrotanoides (Labiatae). Structure and cytotoxic activity relationships (SAR) of the natural and semisynthetic analogues of the presently isolated abietane diterpenoids were studied by using P388 murine leukemia cells.
从唇形科植物阿富汗紫菀的甲醇提取物中分离出7种已知的松香烷二萜类化合物以及11-O-乙酰基和12-O-乙酰基肉豆蔻酸。利用P388小鼠白血病细胞研究了目前分离出的松香烷二萜类化合物的天然和半合成类似物的结构与细胞毒性活性关系（SAR）。
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