聚（ADP - 核糖）：一种古老分子的新功能。

Poly(ADP-ribose): novel functions for an old molecule.

作者信息

Schreiber Valérie, Dantzer Françoise, Ame Jean-Christophe, de Murcia Gilbert

机构信息

Département Intégrité du Génome de l'UMR 7175, Centre National de la Recherche Scientifique, Ecole Supérieure de Biotechnologie de Strasbourg, Boulevard S. Brant, BP 10413, F-67412 Illkirch Cedex, France.

出版信息

Nat Rev Mol Cell Biol. 2006 Jul;7(7):517-28. doi: 10.1038/nrm1963.

DOI:10.1038/nrm1963

PMID:16829982

Abstract

The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique post-translational modification. It regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism.

摘要

由聚（ADP-核糖）聚合酶（PARP）利用烟酰胺腺嘌呤二核苷酸（NAD(+)）合成的带负电荷的聚（ADP-核糖）（PAR）添加到蛋白质上，是一种独特的翻译后修饰。它不仅调节细胞存活和细胞死亡程序，还调节越来越多的其他生物学功能，聚（ADP-核糖）聚合酶家族的新成员也与这些功能相关。这些功能包括转录调控、细胞分裂过程中的端粒黏附和有丝分裂纺锤体形成、细胞内运输和能量代谢。