前包钦格复合体：哺乳动物中可能产生呼吸节律的脑干区域。
Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals.
作者信息
Smith J C, Ellenberger H H, Ballanyi K, Richter D W, Feldman J L
机构信息
Department of Kinesiology, University of California, Los Angeles 90024-1527.
出版信息
Science. 1991 Nov 1;254(5032):726-9. doi: 10.1126/science.1683005.
Abstract
The location of neurons generating the rhythm of breathing in mammals is unknown. By microsection of the neonatal rat brainstem in vitro, a limited region of the ventral medulla (the pre-Bötzinger Complex) that contains neurons essential for rhythmogenesis was identified. Rhythm generation was eliminated by removal of only this region. Medullary slices containing the pre-Bötzinger Complex generated respiratory-related oscillations similar to those generated by the whole brainstem in vitro, and neurons with voltage-dependent pacemaker-like properties were identified in this region. Thus, the respiratory rhythm in the mammalian neonatal nervous system may result from a population of conditional bursting pacemaker neurons in the pre-Bötzinger Complex.
摘要
哺乳动物中产生呼吸节律的神经元位置尚不清楚。通过对新生大鼠脑干进行体外切片，确定了延髓腹侧的一个有限区域（前包钦格复合体），该区域包含对节律产生至关重要的神经元。仅切除该区域就消除了节律产生。含有前包钦格复合体的延髓切片产生了与整个脑干在体外产生的类似呼吸相关振荡，并且在该区域鉴定出具有电压依赖性起搏器样特性的神经元。因此，哺乳动物新生神经系统中的呼吸节律可能源于前包钦格复合体中一群条件性爆发起搏器神经元。
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本文引用的文献
1
Respiratory rhythm generation in the in vitro brain stem-spinal cord preparation of the neonatal rat.新生大鼠体外脑干-脊髓标本中的呼吸节律产生
J Physiol. 1984 Sep;354:173-83. doi: 10.1113/jphysiol.1984.sp015370.
2
Viscerotopic representation of the upper alimentary tract in the medulla oblongata in the rat: the nucleus ambiguus.大鼠延髓中上部消化道的内脏位 representation：疑核。 （注：这里“representation”不太明确准确意思，可能是“表征”之类，需结合更专业背景确定准确译法）
J Comp Neurol. 1987 Aug 22;262(4):546-62. doi: 10.1002/cne.902620408.
3
Localization of respiratory rhythm-generating neurons in the medulla of brainstem-spinal cord preparations from newborn rats.
Neurosci Lett. 1987 Jul 22;78(2):151-5. doi: 10.1016/0304-3940(87)90624-0.
4
Primary respiratory rhythm generator in the medulla of brainstem-spinal cord preparation from newborn rat.
Brain Res. 1988 Apr 5;445(2):314-24. doi: 10.1016/0006-8993(88)91194-8.
5
Differential effects of carbon dioxide and pH on central chemoreceptors in the rat in vitro.二氧化碳和pH值对大鼠离体中枢化学感受器的不同作用。
J Physiol. 1985 Nov;368:679-93. doi: 10.1113/jphysiol.1985.sp015883.
6
In vitro brainstem-spinal cord preparations for study of motor systems for mammalian respiration and locomotion.用于研究哺乳动物呼吸和运动系统的体外脑干-脊髓制备物。
J Neurosci Methods. 1987 Oct;21(2-4):321-33. doi: 10.1016/0165-0270(87)90126-9.
7
Possible modulation of the medullary respiratory rhythm generator by the noradrenergic A5 area: an in vitro study in the newborn rat.
Brain Res. 1989 Apr 24;485(2):325-32. doi: 10.1016/0006-8993(89)90577-5.
8
Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex.对爬行动物和哺乳动物大脑皮层切片中的神经元进行全细胞记录。
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9
Involvement of excitatory amino acids in neurotransmission of inspiratory drive to spinal respiratory motoneurons.兴奋性氨基酸在向脊髓呼吸运动神经元的吸气驱动神经传递中的作用。
J Neurosci. 1989 Jun;9(6):1910-21. doi: 10.1523/JNEUROSCI.09-06-01910.1989.
10
Cellular mechanisms underlying modulation of breathing pattern in mammals.哺乳动物呼吸模式调节的细胞机制。
Ann N Y Acad Sci. 1989;563:114-30. doi: 10.1111/j.1749-6632.1989.tb42194.x.
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