[血清二肽基肽酶IV在佐剂性关节炎大鼠中的临床意义]
[Clinical significance of serum dipeptidyl aminopeptidase IV in rats with adjuvant arthritis].
作者信息
Kaku H, Yoshida K, Mizukawa H, Haruki E, Okazaki K, Inaba G
机构信息
Kanagawa Rehabilitation Institute, Division of Biochemistry, Atsugi-city.
出版信息
Ryumachi. 1991 Jun;31(3):275-81.
Serum dipeptidyl aminopeptidase IV (DAP IV) activity in rats with adjuvant arthritis (AA) were studied. DAP IV activity was significantly low in AA rats (37.7 +/- 14.1 mU/ml, n = 15) compared with control (63.7 +/- 9.0 mU/ml, n = 8) and indomethacin-treated (IDM) AA rats (55.6 +/- 14.2 mU/ml, n = 15). In addition, serum DAP IV activity was inversely correlated with hindpaw arthritis score both in AA rats and IDM-AA rats. Among serum inflammatory index examined, acid soluble glycoprotein, sialic acid were inversely correlated and albumin was positively correlated with DAP IV activity in AA and IDM-AA rats. The role of serum DAP IV remains unknown, but, it seems possible that DAP IV might modify the clinical course of AA rats in connection with its effects on the immune regulatory system.
研究了佐剂性关节炎（AA）大鼠的血清二肽基氨基肽酶IV（DAP IV）活性。与对照组（63.7±9.0 mU/ml，n = 8）和吲哚美辛治疗的（IDM）AA大鼠（55.6±14.2 mU/ml，n = 15）相比，AA大鼠的DAP IV活性显著降低（37.7±14.1 mU/ml，n = 15）。此外，在AA大鼠和IDM-AA大鼠中，血清DAP IV活性与后爪关节炎评分呈负相关。在所检测的血清炎症指标中，AA大鼠和IDM-AA大鼠的酸溶性糖蛋白、唾液酸与DAP IV活性呈负相关，白蛋白与DAP IV活性呈正相关。血清DAP IV的作用尚不清楚，但是，DAP IV可能通过其对免疫调节系统的作用来改变AA大鼠的临床病程，这似乎是有可能的。
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