HELLP综合征的血浆置换治疗：单中心经验

Plasma exchange therapy in HELLP syndrome: a single-center experience.

作者信息

Bayraktaroğlu Ziya, Demirci Fikret, Balat Ozcan, Kutlar Irfan, Okan Vahap, Uğur Gürol

机构信息

Departments of Pediatrics and Transfusion Medicine, Gaziantep University, School of Medicine, Gaziantep, Turkey.

出版信息

Turk J Gastroenterol. 2006 Jun;17(2):99-102.

PMID:16830290

Abstract

BACKGROUND/AIMS: The aim of this study was to investigate the effectiveness of plasma exchange therapy in patients with various forms of hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome.

METHODS

During a three-year period, 13 patients with HELLP syndrome were treated with one or two sessions of plasma exchange after delivery. Diagnosis of hemolysis, elevated liver enzymes, and low platelets syndrome was made according to Sibai's criteria, and the severity of illness was categorized according to platelet counts. Among patients, nine were in class-1 and the remaining four were in class-2. Patients with very high levels of aspartate aminotransferase (AST) (>2000 U/L) and lactate dehydrogenase (LDH) (>3000 U/L) were defined as fulminant type (2 cases).

RESULTS

Rapid improvement in platelet counts was observed after treatment with plasma exchange. All patients survived except the two fulminant hemolysis, elevated liver enzymes, and low platelets syndrome cases.

CONCLUSION

In our study, plasma exchange therapy was effective in patients with severe hemolysis, elevated liver enzymes, and low platelets syndrome, but fulminant cases did not appear to respond to this therapy.

摘要

背景/目的：本研究旨在探讨血浆置换疗法对各种形式溶血、肝酶升高及血小板减少（HELLP）综合征患者的疗效。

方法

在三年期间，13例HELLP综合征患者在分娩后接受了一至两次血浆置换治疗。根据西拜标准诊断溶血、肝酶升高及血小板减少综合征，并根据血小板计数对疾病严重程度进行分类。患者中，9例为1级，其余4例为2级。天冬氨酸转氨酶（AST）水平极高（>2000 U/L）和乳酸脱氢酶（LDH）水平极高（>3000 U/L）的患者被定义为暴发型（2例）。