Guo Chuanhai, Inghirami Giorgio, Ibrahim Sherif, Sen Filiz
Department of Pathology, New York University Medical Center, New York 10016, USA.
Arch Pathol Lab Med. 2006 Jul;130(7):1075-6. doi: 10.5858/2006-130-1075-EASWIA.
Therapy-related acute myeloid leukemias arise as a result of cytotoxic chemotherapy and/or radiation therapy. The most common types of acute myeloid leukemia arising in this setting are acute myeloid leukemia with maturation, and lesser numbers of acute myelomonocytic leukemia, acute monocytic leukemia, acute erythroleukemia, or acute megakaryocytic leukemia. We present a patient with multiple myeloma who was treated with melphalan and 4 years later developed acute erythroid leukemia. The morphologic diagnosis of pure erythroid leukemia developing in the setting of multiple myeloma may be challenging.
治疗相关的急性髓系白血病是细胞毒性化疗和/或放射治疗的结果。在此情况下出现的最常见的急性髓系白血病类型是伴有成熟的急性髓系白血病，以及数量较少的急性粒单核细胞白血病、急性单核细胞白血病、急性红白血病或急性巨核细胞白血病。我们报告一例接受美法仑治疗的多发性骨髓瘤患者，4年后发生急性红白血病。在多发性骨髓瘤背景下发生的纯红白血病的形态学诊断可能具有挑战性。
