Cutter Jennifer L, Kurozumi Kazuhiko, Chiocca E Antonio, Kaur Balveen
Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University Medical Center, 410 West 12th Avenue, Columbus, OH 43210, USA.
Expert Rev Anticancer Ther. 2006 Jul;6(7):1053-64. doi: 10.1586/14737140.6.7.1053.
Primary glioblastoma multiforme is an aggressive brain tumor that has no cure. Current treatments include gross resection of the tumor, radiation and chemotherapy. Despite valiant efforts, prognosis remains dismal. A promising new technique involves the use of oncolytic viruses that can specifically replicate and lyse in cancers, without spreading to normal tissues. Currently, these are being tested in relevant preclinical models and clinical trials as a therapeutic modality for many types of cancer. Results from recent clinical trials with oncolytic viruses have revealed the safety of this approach, although evidence for efficacy remains elusive. Oncolytic viral strategies are summarized in this review, with a focus on therapies used in brain tumors.
原发性多形性胶质母细胞瘤是一种侵袭性脑肿瘤，无法治愈。目前的治疗方法包括肿瘤大体切除、放疗和化疗。尽管付出了巨大努力，但预后仍然不佳。一种有前景的新技术涉及使用溶瘤病毒，这种病毒可以在癌症中特异性复制并裂解，而不会扩散到正常组织。目前，这些病毒正在相关的临床前模型和临床试验中作为多种癌症的治疗方式进行测试。溶瘤病毒近期临床试验的结果显示了这种方法的安全性，尽管疗效证据仍然难以捉摸。本综述总结了溶瘤病毒策略，重点是用于脑肿瘤的治疗方法。
