Massano João, Regateiro Frederico S, Januário Gustavo, Ferreira Artur
Faculty of Medicine, University of Coimbra, Coimbra University Hospital, Coimbra, Portugal.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Jul;102(1):67-76. doi: 10.1016/j.tripleo.2005.07.038. Epub 2006 Jan 10.
Oral squamous cell carcinoma has a remarkable incidence worldwide and a fairly onerous prognosis, encouraging further research on factors that might modify disease outcome. In this review article, the authors approach the factors that may exert influence on the prognosis and eventually guide the selection of patients for more aggressive therapies. Published scientific data was collected, selected, and grouped into 3 main clusters: patient-, tumor-, and treatment-related factors. Well established aspects are discussed, but also those less common or with only supposed usefulness. Disease staging, extracapsular dissemination, resection margin free of disease, and tumor thickness are factors with high influence on the prognosis. There has been an increasing interest in the study of tumor molecular factors, and some have been strongly correlated with the outcome, showing promising pathways for the future development of more effective prognosis systems and anticancer therapies.
口腔鳞状细胞癌在全球范围内发病率显著，预后相当严峻，这促使人们进一步研究可能改变疾病转归的因素。在这篇综述文章中，作者探讨了可能影响预后并最终指导选择更积极治疗方案的因素。收集、筛选已发表的科学数据，并将其分为3个主要类别：患者相关因素、肿瘤相关因素和治疗相关因素。文中不仅讨论了已确立的方面，也探讨了那些不太常见或仅具有假定用途的方面。疾病分期、包膜外扩散、切缘无肿瘤以及肿瘤厚度是对预后有高度影响的因素。对肿瘤分子因素的研究兴趣日益增加，其中一些因素与预后密切相关，为未来开发更有效的预后系统和抗癌疗法展示了有前景的途径。
