骨形态发生蛋白（BMPs）及其拮抗剂在成体骨中的作用。
Function of BMPs and BMP antagonists in adult bone.
作者信息
Abe Etsuko
机构信息
Division of Endocrinology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1055, New York, NY 10029, USA.
出版信息
Ann N Y Acad Sci. 2006 Apr;1068:41-53. doi: 10.1196/annals.1346.007.
The expression and function of BMPs and BMPs in bone tissues have been studied for a long time because of their remarkable activities. However, their biological functions in normal bone remodeling in adults were not fully understood until recently. Advanced technologies using gene manipulation were used to study their roles in adulthood. In addition, findings of new BMP antagonists and the effect of Wnt-canonical pathways on bone features also provided new insights in bone studies.
由于骨形态发生蛋白（BMPs）具有显著活性，其在骨组织中的表达和功能已被研究了很长时间。然而，直到最近，它们在成骨正常骨重塑中的生物学功能仍未被完全理解。利用基因操作的先进技术被用于研究它们在成年期的作用。此外，新的BMP拮抗剂的发现以及Wnt经典途径对骨特征的影响也为骨研究提供了新的见解。
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