Gazzerro Elisabetta, Minetti Carlo
Unit of Muscular and Neurodegenerative Disorders, Gaslini Institute, L.go G.Gaslini 5, 16148 Genoa, Italy.
Curr Opin Pharmacol. 2007 Jun;7(3):325-33. doi: 10.1016/j.coph.2007.01.003. Epub 2007 May 1.
Bone morphogenetic proteins (BMPs) play an essential role in skeletal tissue, as they induce the commitment of mesenchymal cells toward cells of the osteoblastic lineage and also enhance the differentiated function of the osteoblast. BMPs are required for skeletal development, maintenance of adult bone homeostasis and fracture healing. BMP actions are tempered by extracellular and intracellular signals that block BMP signal transduction at multiple levels. Identification of these BMP regulatory molecules allows us to investigate their role in diseases that affect skeletal function and could provide a novel therapeutic intervention point for treatment. Both extracellular and intracellular antagonists are regulated by BMPs, indicating the existence and need for local feedback mechanisms to modulate BMP biological responses.
骨形态发生蛋白（BMPs）在骨骼组织中发挥着至关重要的作用，因为它们诱导间充质细胞向成骨细胞谱系的细胞定向分化，还能增强成骨细胞的分化功能。骨骼发育、维持成年骨内环境稳定以及骨折愈合都需要BMPs。BMP的作用受到细胞外和细胞内信号的调节，这些信号在多个层面阻断BMP信号转导。鉴定这些BMP调节分子使我们能够研究它们在影响骨骼功能的疾病中的作用，并可能为治疗提供新的治疗干预点。细胞外和细胞内拮抗剂均受BMPs调节，这表明存在并需要局部反馈机制来调节BMP的生物学反应。
