Mechri Anwar, Sayadi Latifa, Frih-Ayed Mahbouba, Gaha Lotfi
Unité de Recherche en Santé Mentale, Service de Psychiatrie, Monastir.
Tunis Med. 2006 Apr;84(4):233-7.
The aim of this study was to analyse the risk factors of mental disorders in epileptic patients. It was a case-control study concerning 200 epileptic out-patients examined in the department of Neurology of Monastir University Hospital during four months. Patients had been divided into two groups: the first (study-group) included 100 epileptic patients with mental disorders compared with a control-group of 100 epileptic patients without mental disorders. General seizures were significantly more frequent in the study-group (78%) than in the control-group (57%) (p=0,001). In the study-group, mental disorders were dominated by the behavioraland character disorders. Existence of temporal focus in electroencephalography or structural abnormality in tomodensitometry was more frequent in epileptic patients with mental disorders. The medium term course of epilepsy was significantly longer in the study-group (15.38 years versus 10?35 years; p=0.00007). Association of antiepileptic agents was significantly more frequent in study-group (38% versus 15%; p= 0,0002). However, no correlations were found between mental disorders and sex, age at onset of epileptic seizures and seizures frequency. The results of our study suggest that epilepsy characteristics and anti-epileptic treatment seem to be the principal factors of mental disorders in epileptic patients.
本研究的目的是分析癫痫患者精神障碍的危险因素。这是一项病例对照研究，涉及在四个月内于莫纳斯提尔大学医院神经科检查的200例癫痫门诊患者。患者被分为两组：第一组（研究组）包括100例患有精神障碍的癫痫患者，与100例无精神障碍的癫痫患者对照组进行比较。全身发作在研究组（78%）中明显比对照组（57%）更频繁（p = 0.001）。在研究组中，精神障碍以行为和性格障碍为主。脑电图存在颞叶病灶或脑断层扫描存在结构异常在患有精神障碍的癫痫患者中更为常见。癫痫的中期病程在研究组中明显更长（15.38年对10.35年；p = 0.00007）。抗癫痫药物联合使用在研究组中明显更频繁（38%对15%；p = 0.0002）。然而，未发现精神障碍与性别、癫痫发作起始年龄和发作频率之间存在相关性。我们的研究结果表明，癫痫特征和抗癫痫治疗似乎是癫痫患者精神障碍的主要因素。
