Ladurelle N, Duterte-Boucher D, Costentin J
CNRS URA 1170 UFR de Médecine et Pharmacie de Rouen, Saint-Etienne-du-Rouvray, France.
Fundam Clin Pharmacol. 1991;5(6):481-90. doi: 10.1111/j.1472-8206.1991.tb00734.x.
In food-deprived mice the D1 dopamine agonist SKF 38393 induced dose dependent anorexia (ED50 = 2.6 mg/kg). This effect was reversed by the D1 antagonist SCH 23390. In similar conditions, the D2 dopamine agonist RU 24926 also induced dose dependent anorexia (ED50 = 0.19 mg/kg). This effect was reversed by the D2 antagonist (+/-) sulpiride. The mixed D1/D2 agonist apomorphine also induced an anorectic effect (150 micrograms/kg sc) which was completely reversed by (+/-) sulpiride (25 mg/kg, ip) but unaffected by SCH 23390 (5-30 micrograms/kg). The dose response curve obtained by associating SKF 38393 (2.5 mg/kg) with increasing doses of RU 24926 was roughly parallel to that obtained with RU 24926 alone. This indicates that effects of two drugs were additive. Although both D1 and D2 receptors regulate food consumption, the anorectic effect of apomorphine appears to involve only D2 receptors.
在食物匮乏的小鼠中，D1多巴胺激动剂SKF 38393可诱导剂量依赖性厌食（半数有效剂量[ED50]=2.6毫克/千克）。这种效应可被D1拮抗剂SCH 23390逆转。在类似条件下，D2多巴胺激动剂RU 24926也可诱导剂量依赖性厌食（ED50=0.19毫克/千克）。这种效应可被D2拮抗剂（±）舒必利逆转。混合D1/D2激动剂阿扑吗啡也可诱导厌食效应（皮下注射150微克/千克），该效应可被（±）舒必利（腹腔注射25毫克/千克）完全逆转，但不受SCH 23390（5 - 30微克/千克）影响。将SKF 38393（2.5毫克/千克）与递增剂量的RU 24926联合使用所获得的剂量反应曲线与单独使用RU 24926时大致平行。这表明两种药物的效应是相加的。尽管D1和D2受体都调节食物摄入，但阿扑吗啡的厌食效应似乎仅涉及D2受体。
