Tsau Y K, Chen C H
Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
J Formos Med Assoc. 1991 Aug;90(8):764-8.
Twenty Wistar rats were nephrectomized unilaterally or sham-operated for the study of compensatory response of renal growth, including kidney weight, creatinine clearance (Ccr), and the role of insulin-like growth factor 1 (IGF-1). The remaining kidney weight had increased 26% above the control level on day 6, and 58% on day 28 after nephrectomy. The overall Ccr in rats with one functioning kidney was 75%, 88%, and 87% of the control values in two-kidney rats on days 1, 6, and 28, respectively after surgery. Serum IGF-1 concentrations were not different between the nephrectomy and sham groups. There was a nearly 2-fold increase in renal tissue IGF-1 concentration on day 6 in nephrectomized rats versus sham-operated controls (107.1 +/- 19.1 and 61.0 +/- 6.1 ng/g tissue, respectively), but no difference between the 2 groups on day 28 after surgery. Urinary IGF-1 excretion was found to be significantly elevated on day 6 after nephrectomy in association with high renal IGF-1 levels. This data suggests that renal IGF-1 production may be involved during the later phases of rapid compensatory renal growth.
将20只Wistar大鼠单侧肾切除或进行假手术，以研究肾脏生长的代偿反应，包括肾脏重量、肌酐清除率（Ccr）以及胰岛素样生长因子1（IGF-1）的作用。肾切除术后第6天，剩余肾脏重量比对照水平增加了26%，第28天增加了58%。单肾大鼠术后第1天、第6天和第28天的总体Ccr分别为双肾大鼠对照值的75%、88%和87%。肾切除组和假手术组的血清IGF-1浓度无差异。与假手术对照组相比，肾切除大鼠术后第6天肾组织IGF-1浓度增加了近2倍（分别为107.1±19.1和61.0±6.1 ng/g组织），但术后第28天两组之间无差异。肾切除术后第6天，与肾脏IGF-1水平升高相关，尿IGF-1排泄显著升高。该数据表明，肾脏IGF-1的产生可能参与了肾脏快速代偿生长的后期阶段。
