哌啶类：一类新型脲酶抑制剂。
Piperidines: a new class of urease inhibitors.
作者信息
Khan Khalid Mohammed, Saify Zafar S, Arif Lodhi Muhammad, Butt Naeem, Perveen Shahnaz, Maharvi Ghulam Murtaza, Choudhary Muhammad Iqbal
机构信息
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
出版信息
Nat Prod Res. 2006 May 20;20(6):523-30. doi: 10.1080/1478641500059383.
A variety of piperidines (2-12, 14-26) with variable substituents at N-atoms have been synthesized and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 31.97 to 254 microM. The size and electron-donating or -withdrawing effects of substituents influence the activity, which lead to the formation of urease inhibitors.
已合成了多种在氮原子上具有不同取代基的哌啶（2 - 12、14 - 26），并将其作为脲酶抑制剂进行了评估。合成的化合物表现出不同程度的脲酶抑制活性，范围为31.97至254微摩尔。取代基的大小以及给电子或吸电子效应会影响活性，这导致了脲酶抑制剂的形成。
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