Sivapriya Kirubakaran, Suguna Perumal, Banerjee Arun, Saravanan Vadivelu, Rao Desirazu N, Chandrasekaran Srinivasan
Department of Organic Chemistry, Indian Institute of Science, Bangalore, India.
Bioorg Med Chem Lett. 2007 Nov 15;17(22):6387-91. doi: 10.1016/j.bmcl.2007.07.085. Epub 2007 Aug 22.
A facile, one-pot synthesis of thio and selenourea derivatives from amines using tetrathiomolybdate 1 and tetraselenotungstate 2 as sulfur and selenium transfer reagents, respectively, is reported. The compounds were tested for their activity as urease inhibitors and some of the compounds showed potent activity in the nanomolar range towards jack bean urease.
据报道，使用钼酸四硫盐1和钨酸四硒盐2分别作为硫和硒转移试剂，可从胺类化合物中简便地一锅法合成硫脲和硒脲衍生物。对这些化合物作为脲酶抑制剂的活性进行了测试，其中一些化合物对刀豆脲酶表现出纳摩尔范围内的强效活性。
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