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TS-1、多西他赛和顺铂联合化疗对一名晚期食管癌患者产生显著疗效

[Combination chemotherapy of TS-1, docetaxel and CDDP produces a remarkable response in a patient with advanced esophageal cancer].

作者信息

Yasumoto Kazuo, Kitakata Hidekazu, Yamashita Kaname, Omote Kazuhiko, Takahashi Yutaka

机构信息

Division of Surgical Oncology, Cancer Research Institute, Kanazawa University.

出版信息

Gan To Kagaku Ryoho. 2006 Jul;33(7):965-7.

Abstract

We report a patient with advanced esophageal cancer who achieved a complete response to combination chemotherapy of TS-1, docetaxel and CDDP. A 74-year-old man was admitted to our hospital for advanced esophageal cancer with a complaint of dysphagia. He received chemotherapy, consisting of TS-1 100 mg/body, docetaxel 35 mg/m(2), and CDDP 10 mg/m(2), every 3 weeks. TS-1 was administered for 14 days followed by 7 days rest; docetaxel and CDDP were administered by intravenous infusion at day one and day 8 after beginning TS-1. After three cycles of chemotherapy, his dysphagia disappeared, and endoscopic examination of the primary esophageal tumor showed a complete response. Endoscopic examination with biopsy confirmed the disappearance of the esophageal cancer. No severe side effects were observed during this chemotherapy. Combination chemotherapy of TS-1, docetaxel, and CDDP can thus be effective for advanced esophageal cancer.

摘要

我们报告了一名晚期食管癌患者,其对替吉奥(TS-1)、多西他赛和顺铂的联合化疗取得了完全缓解。一名74岁男性因晚期食管癌伴吞咽困难入院。他每3周接受一次化疗,方案为替吉奥100mg/体、多西他赛35mg/m²和顺铂10mg/m²。替吉奥服用14天,随后休息7天;多西他赛和顺铂在开始服用替吉奥后的第1天和第8天通过静脉输注给药。三个化疗周期后,他的吞咽困难消失,对原发性食管肿瘤的内镜检查显示完全缓解。活检的内镜检查证实食管癌消失。在此化疗期间未观察到严重副作用。因此,替吉奥、多西他赛和顺铂的联合化疗对晚期食管癌可能有效。

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