一串红克罗烷二萜类化合物的完整氢谱和碳谱归属

Complete 1H and 13C NMR assignments of clerodane diterpenoids of Salvia splendens.

作者信息

Fontana Gianfranco, Savona Giuseppe, Rodríguez Benjamín

机构信息

Dipartimento di Chimica Organica E. Paternò, Università degli Studi di Palermo, Parco d'Orleans 2, I 90128 Palermo, Italy.

出版信息

Magn Reson Chem. 2006 Oct;44(10):962-5. doi: 10.1002/mrc.1869.

DOI:10.1002/mrc.1869

PMID:16835898

Abstract

Unambiguous and complete assignments of 1H and 13C NMR chemical shifts for five clerodane diterpenes, four of them isolated from Salvia splendens (salviarin, splendidin and splenolides A and B) and one obtained by acetylation of splenolide A, are presented. The assignments are based on 2D shift-correlated [1H,1H-COSY, 1H,13C-gHSQC-1J(C,H) and 1H,13C-gHMBC-nJ(C,H) (n=2 and 3)] and nuclear Overhauser effect (NOE) experiments. The conformation of the rings of these compounds is supported by the 3J(H,H) values and NOE results.

摘要

给出了五种克罗烷二萜的1H和13C NMR化学位移的明确且完整归属，其中四种从鼠尾草（丹参素、丹参酮和丹参内酯A和B）中分离得到，另一种通过丹参内酯A的乙酰化获得。这些归属基于二维位移相关实验[1H,1H-COSY、1H,13C-gHSQC-1J(C,H)和1H,13C-gHMBC-nJ(C,H)（n = 2和3）]以及核Overhauser效应（NOE）实验。这些化合物环的构象由3J(H,H)值和NOE结果支持。