Fontana Gianfranco, Savona Giuseppe, Rodríguez Benjamín
Dipartimento di Chimica Organica E. Paternò, Università degli Studi di Palermo, Parco d'Orleans 2, I 90128 Palermo, Italy.
Magn Reson Chem. 2006 Oct;44(10):962-5. doi: 10.1002/mrc.1869.
Unambiguous and complete assignments of 1H and 13C NMR chemical shifts for five clerodane diterpenes, four of them isolated from Salvia splendens (salviarin, splendidin and splenolides A and B) and one obtained by acetylation of splenolide A, are presented. The assignments are based on 2D shift-correlated [1H,1H-COSY, 1H,13C-gHSQC-1J(C,H) and 1H,13C-gHMBC-nJ(C,H) (n=2 and 3)] and nuclear Overhauser effect (NOE) experiments. The conformation of the rings of these compounds is supported by the 3J(H,H) values and NOE results.
给出了五种克罗烷二萜的1H和13C NMR化学位移的明确且完整归属，其中四种从鼠尾草（丹参素、丹参酮和丹参内酯A和B）中分离得到，另一种通过丹参内酯A的乙酰化获得。这些归属基于二维位移相关实验[1H,1H-COSY、1H,13C-gHSQC-1J(C,H)和1H,13C-gHMBC-nJ(C,H)（n = 2和3）]以及核Overhauser效应（NOE）实验。这些化合物环的构象由3J(H,H)值和NOE结果支持。
