Okumura Akihisa, Watanabe Kazuyoshi, Negoro Tamiko
Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
Epilepsy Res. 2006 Aug;70 Suppl 1:S168-73. doi: 10.1016/j.eplepsyres.2005.11.019. Epub 2006 Jul 11.
Benign partial epilepsy in infancy (BPEI) is an infantile epilepsy with excellent seizure and developmental outcome proposed by Watanabe et al. Our telephone interview survey revealed that the long-term outcome of patients with BPEI was also excellent over 8 years of age. Six of 39 patients did not fulfill the criteria of BPEI by the last follow-up. Two patients had a recurrence of unprovoked seizure beyond 2 years of age, three had cognitive problems (mild mental retardation in two and Asperger syndrome in one) and the other had both a recurrence of seizure and mild mental retardation. These results indicates that a large majority of patients diagnosed as possible BPEI at 2 years of age did not have a recurrence of unprovoked seizures and mental problems beyond 8 years of age. Our study also suggested a presence of some marginal syndromes of BPEI. An association of paroxysmal kinesigenic choreoathetosis was observed in three patients. Another three patients had experienced seizures with mild gastroenteritis. The seizure outcome of three patients with mild cognitive problems was quite excellent. These patients can be grouped as a marginal syndrome of BPEI.
婴儿期良性部分性癫痫（BPEI）是渡边等人提出的一种癫痫类型，其癫痫发作及发育预后良好。我们的电话访谈调查显示，BPEI患者8岁以上的长期预后同样良好。在39例患者中，有6例在最后一次随访时不符合BPEI的标准。2例患者在2岁以后出现无诱因癫痫复发，3例有认知问题（2例轻度智力低下，1例阿斯伯格综合征），另1例既有癫痫复发又有轻度智力低下。这些结果表明，大多数在2岁时被诊断为可能患有BPEI的患者在8岁以后没有出现无诱因癫痫复发和精神问题。我们的研究还提示存在一些BPEI的边缘综合征。3例患者观察到阵发性运动诱发性舞蹈手足徐动症。另外3例患者在患轻度胃肠炎时出现癫痫发作。3例有轻度认知问题患者的癫痫发作预后相当良好。这些患者可归为BPEI的边缘综合征。
