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静脉血栓栓塞与癌症:意大利医学肿瘤学会(AIOM)指南

Venous thromboembolism and cancer: guidelines of the Italian Association of Medical Oncology (AIOM).

作者信息

Mandalà M, Falanga A, Piccioli A, Prandoni P, Pogliani E M, Labianca R, Barni S

机构信息

Division of Medical Oncology, Azienda Ospedaliera Treviglio-Caravaggio, Treviglio-Caravaggio Hospital P.le Ospedale 1, 24047 Treviglio, Bergamo, Italy.

出版信息

Crit Rev Oncol Hematol. 2006 Sep;59(3):194-204. doi: 10.1016/j.critrevonc.2006.05.001. Epub 2006 Jul 11.

Abstract

Thromboembolic complications represent one of the most important cause of morbidity and mortality in cancer patients. Although several data have been published demonstrating the strong association between cancer and venous thromboembolism (VTE), there is poor perception, among oncologists, of the level of risk of thrombosis and of relevance of managing VTE in these patients. The Associazione Italiana di Oncologia Medica (AIOM) has provided some recommendations to direct clinical practice according to evidence-based data concerning cancer and VTE. In fact, we conducted an extensive literature review (1996-2005) to produce evidence-based recommendations to improve perceptions of the magnitude of this risk among Italian medical and surgical oncologists and alert on the new approaches to prophylaxis and treatment of VTE in cancer patients. Levels of evidence are given according to a five-point rating system, and similarly for each key recommendation a five-point rating system suggests if the evidence is strong and indicate that the benefits do, or do not, outweigh risks and burden.

摘要

血栓栓塞并发症是癌症患者发病和死亡的最重要原因之一。尽管已经发表了一些数据,证明癌症与静脉血栓栓塞(VTE)之间存在密切关联,但肿瘤学家对这些患者的血栓形成风险水平以及管理VTE的相关性认识不足。意大利医学肿瘤学会(AIOM)根据有关癌症和VTE的循证数据提供了一些指导临床实践的建议。事实上,我们进行了广泛的文献综述(1996 - 2005年),以制定循证建议,提高意大利医学和外科肿瘤学家对这种风险程度的认识,并提醒他们关注癌症患者VTE预防和治疗的新方法。证据水平根据五分制评级系统给出,同样,对于每个关键建议,五分制评级系统表明证据是否充分,并指出益处是否大于风险和负担。

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