Ogawa Aiko, Emori Tetsuro, Sumita Wakako, Watanabe Atsuyuki, Fujio Hideki, Miyaji Katsumasa, Ohe Tohru
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Acta Med Okayama. 2006 Jun;60(3):191-5. doi: 10.18926/AMO/30744.
A 52-year-old obese woman was admitted to our institution for evaluation of dyspnea and pulmonary hypertension (PH). Polysomnography revealed severe obstructive sleep apnea (OSA) with an apnea hypopnea index of 99.8. Treatment with nocturnal continuous positive airway pressure (CPAP) resulted in correction of daytime hypoxemia, hypercapnia, and near-normalization of pulmonary artery pressure. To our knowledge, this is the most severe case of OSA-associated PH (approximately70 mmHg) reported to date, and it was successfully treated with nocturnal CPAP. This case demonstrates that OSA should be considered and polysomnography performed in all patients with PH, irrespective of severity, and that nocturnal CPAP has therapeutic effects on both OSA and daytime PH.
一名52岁肥胖女性因呼吸困难和肺动脉高压（PH）入我院评估。多导睡眠图显示严重阻塞性睡眠呼吸暂停（OSA），呼吸暂停低通气指数为99.8。夜间持续气道正压通气（CPAP）治疗纠正了日间低氧血症、高碳酸血症，并使肺动脉压接近正常。据我们所知，这是迄今为止报道的最严重的OSA相关性PH病例（约70 mmHg），且通过夜间CPAP治疗成功治愈。该病例表明，对于所有PH患者，无论严重程度如何，均应考虑OSA并进行多导睡眠图检查，且夜间CPAP对OSA和日间PH均有治疗作用。
