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γ-谷氨酰转移酶对心血管事件的预后作用

[The prognostic role of gamma-glutamyltransferase for cardiovascular events].

作者信息

Emdin Michele, Pompella Alfonso, Passino Claudio, Paolicchi Aldo

机构信息

Unità Operativa Medicina Cardiovascolare, Istituto di Fisiologia Clinica, CNR, Pisa.

出版信息

Recenti Prog Med. 2006 May;97(5):241-5.

Abstract

Serum gamma-glutamyltransferasis activity is a low-cost, highly sensitive laboratory test. Though it is currently considered as an index of hepato-biliary dysfunction and alcohol abuse, recent epidemiological and pathologic studies have proposed its independent role in the pathogenesis and clinical evolution of cardiovascular diseases brought by atherosclerosis, associated with a gamma-glutamyltransferase-linked prooxidant effect of glutathione catabolism within the plaque.

摘要

血清γ-谷氨酰转移酶活性是一种低成本、高灵敏度的实验室检测指标。尽管目前它被视为肝胆功能障碍和酒精滥用的指标,但最近的流行病学和病理学研究表明,它在动脉粥样硬化所致心血管疾病的发病机制和临床演变中具有独立作用,这与斑块内谷胱甘肽分解代谢的γ-谷氨酰转移酶相关促氧化作用有关。

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